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atrial cardiomyocytes  (Axol Bioscience)


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    Structured Review

    Axol Bioscience atrial cardiomyocytes
    Atrial Cardiomyocytes, supplied by Axol Bioscience, used in various techniques. Bioz Stars score: 94/100, based on 15 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/atrial+cardiomyocytes/Human+iPSC-Derived+Atrial+Cardiomyocytes/10__1042_slash_bst20253028-92-20-30
    Average 94 stars, based on 15 article reviews
    atrial cardiomyocytes - by Bioz Stars, 2026-09
    94/100 stars

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    Related Articles

    Microelectrode Array:

    Article Title: Activation of IP 3 R in atrial cardiomyocytes leads to generation of cytosolic cAMP.
    Article Snippet: .. For multielectrode array (MEA) experiments, human induced pluripotent stem cells-derived atrial cardiomyocytes (hiPSC-ACMs) (ax2518, Axol Bioscience, UK) were cultured at 5.0 105 cells/well on a 768-channel 48-well Axion CytoviewMEA 48 plate (M768-tMEA-48B, Axion Biosystems, USA) coated with Axol’s Fibronectin Coating Solution (ax0049, Axol Bioscience, UK) at 37 C in a 5% CO2–95% air atmosphere. ..

    Article Title: Human iPSCs: atrial versus ventricular cardiomyocytes and their functional and pharmacological differences
    Article Snippet: .. Representative fAP traces (A), raster plots (B), LEAP waveforms (C) and contractility waveforms (D) from Axol’s human iPSC-derived ventricular and atrial cardiomyocytes under control conditions using the Axion MEA system (Axol Bioscience in-house data). force (CF) while markedly reducing the BR (Figure 6A). ..

    Article Title: Activation of IP 3 R in atrial cardiomyocytes leads to generation of cytosolic cAMP
    Article Snippet: .. For multielectrode array (MEA) experiments, human induced pluripotent stem cells-derived atrial cardiomyocytes (hiPSC-ACMs) (ax2518, Axol Bioscience, UK) were cultured at 5.0 × 10 5 cells/well on a 768-channel 48-well Axion Cytoview MEA 48 plate (M768-tMEA-48B, Axion Biosystems, USA) coated with Axol’s Fibronectin Coating Solution (ax0049, Axol Bioscience, UK) at 37°C in a 5% CO 2 –95% air atmosphere. ..

    Cell Culture:

    Article Title: Activation of IP 3 R in atrial cardiomyocytes leads to generation of cytosolic cAMP.
    Article Snippet: .. For multielectrode array (MEA) experiments, human induced pluripotent stem cells-derived atrial cardiomyocytes (hiPSC-ACMs) (ax2518, Axol Bioscience, UK) were cultured at 5.0 105 cells/well on a 768-channel 48-well Axion CytoviewMEA 48 plate (M768-tMEA-48B, Axion Biosystems, USA) coated with Axol’s Fibronectin Coating Solution (ax0049, Axol Bioscience, UK) at 37 C in a 5% CO2–95% air atmosphere. ..

    Article Title: Semaglutide Modulates Proinflammatory Epicardial Adipogenesis With Paracrine Effects on hiPSC-Atrial Cardiomyocytes.
    Article Snippet: .. Human induced pluripotent stem cell-derived atrial cardiomyocytes (hiPSCaCMs) (AxolBio) were cultured in vitro using a cardiomyocyte maintenance medium (AxolBio). ..

    Article Title: Semaglutide Modulates Proinflammatory Epicardial Adipogenesis With Paracrine Effects on hiPSC-Atrial Cardiomyocytes
    Article Snippet: Volcano plots were performed using GraphPad 9. .. Human induced pluripotent stem cell-derived atrial cardiomyocytes (hiPSC-aCMs) (AxolBio) were cultured in vitro using a cardiomyocyte maintenance medium (AxolBio). ..

    Article Title: Activation of IP 3 R in atrial cardiomyocytes leads to generation of cytosolic cAMP
    Article Snippet: .. For multielectrode array (MEA) experiments, human induced pluripotent stem cells-derived atrial cardiomyocytes (hiPSC-ACMs) (ax2518, Axol Bioscience, UK) were cultured at 5.0 × 10 5 cells/well on a 768-channel 48-well Axion Cytoview MEA 48 plate (M768-tMEA-48B, Axion Biosystems, USA) coated with Axol’s Fibronectin Coating Solution (ax0049, Axol Bioscience, UK) at 37°C in a 5% CO 2 –95% air atmosphere. ..

    Control:

    Article Title: Human iPSCs: atrial versus ventricular cardiomyocytes and their functional and pharmacological differences
    Article Snippet: .. Representative fAP traces (A), raster plots (B), LEAP waveforms (C) and contractility waveforms (D) from Axol’s human iPSC-derived ventricular and atrial cardiomyocytes under control conditions using the Axion MEA system (Axol Bioscience in-house data). force (CF) while markedly reducing the BR (Figure 6A). ..

    In Vitro:

    Article Title: Semaglutide Modulates Proinflammatory Epicardial Adipogenesis With Paracrine Effects on hiPSC-Atrial Cardiomyocytes.
    Article Snippet: .. Human induced pluripotent stem cell-derived atrial cardiomyocytes (hiPSCaCMs) (AxolBio) were cultured in vitro using a cardiomyocyte maintenance medium (AxolBio). ..

    Article Title: Semaglutide Modulates Proinflammatory Epicardial Adipogenesis With Paracrine Effects on hiPSC-Atrial Cardiomyocytes
    Article Snippet: Volcano plots were performed using GraphPad 9. .. Human induced pluripotent stem cell-derived atrial cardiomyocytes (hiPSC-aCMs) (AxolBio) were cultured in vitro using a cardiomyocyte maintenance medium (AxolBio). ..

    Expressing:

    Article Title: FABP4 Enhances Lipidic and Fibrotic Cardiac Structural and Ca <sup>2+</sup> Dynamic Changes
    Article Snippet: Circ Arrhythm Electrophysiol.. 2024;17:e012683.. DOI: 10.1161/CIRCEP.123.012683 September 2024 Correspondence to: Sonia Eiras, PhD, Laboratorio 6, IDIS, Planta-2.C/Choupana s/n, Complejo Hospitalario Universitario, de Santiago de Compostela, Santiago de Compostela 15706, A Coruña, Spain.

    Real-time Polymerase Chain Reaction:

    Article Title: FABP4 Enhances Lipidic and Fibrotic Cardiac Structural and Ca <sup>2+</sup> Dynamic Changes
    Article Snippet: Circ Arrhythm Electrophysiol.. 2024;17:e012683.. DOI: 10.1161/CIRCEP.123.012683 September 2024 Correspondence to: Sonia Eiras, PhD, Laboratorio 6, IDIS, Planta-2.C/Choupana s/n, Complejo Hospitalario Universitario, de Santiago de Compostela, Santiago de Compostela 15706, A Coruña, Spain.

    Immunocytochemistry:

    Article Title: FABP4 Enhances Lipidic and Fibrotic Cardiac Structural and Ca <sup>2+</sup> Dynamic Changes
    Article Snippet: Circ Arrhythm Electrophysiol.. 2024;17:e012683.. DOI: 10.1161/CIRCEP.123.012683 September 2024 Correspondence to: Sonia Eiras, PhD, Laboratorio 6, IDIS, Planta-2.C/Choupana s/n, Complejo Hospitalario Universitario, de Santiago de Compostela, Santiago de Compostela 15706, A Coruña, Spain.



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    a Flow cytometry plots of <t>GFP</t> + <t>TTN-GFP</t> hiPSC-CMs following CM-AI purification stained for cardiac troponin T (cTnT-APC). b Flow cytometry of untagged 19.9.11 hiPSC-CMs stained with cTnT-APC following CM-AI purification. c Summary of cTnT+ cell percentages from three independent differentiations using TTN-GFP and 19.9.11 hiPSC lines ( n = 3 per line). Average purity was 92.0 ± 1.0% and 94.3 ± 7.2%, respectively. No residual expression of pluripotency markers (NANOG, POU5F1) detected post-CM-AI processing (qRT-PCR; Supplementary Table ). Data are mean ± s.d.
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    Image Search Results


    a Flow cytometry plots of GFP + TTN-GFP hiPSC-CMs following CM-AI purification stained for cardiac troponin T (cTnT-APC). b Flow cytometry of untagged 19.9.11 hiPSC-CMs stained with cTnT-APC following CM-AI purification. c Summary of cTnT+ cell percentages from three independent differentiations using TTN-GFP and 19.9.11 hiPSC lines ( n = 3 per line). Average purity was 92.0 ± 1.0% and 94.3 ± 7.2%, respectively. No residual expression of pluripotency markers (NANOG, POU5F1) detected post-CM-AI processing (qRT-PCR; Supplementary Table ). Data are mean ± s.d.

    Journal: Communications Biology

    Article Title: AI-guided laser purification of human iPSC-derived cardiomyocytes for next-generation cardiac cell manufacturing

    doi: 10.1038/s42003-025-08162-0

    Figure Lengend Snippet: a Flow cytometry plots of GFP + TTN-GFP hiPSC-CMs following CM-AI purification stained for cardiac troponin T (cTnT-APC). b Flow cytometry of untagged 19.9.11 hiPSC-CMs stained with cTnT-APC following CM-AI purification. c Summary of cTnT+ cell percentages from three independent differentiations using TTN-GFP and 19.9.11 hiPSC lines ( n = 3 per line). Average purity was 92.0 ± 1.0% and 94.3 ± 7.2%, respectively. No residual expression of pluripotency markers (NANOG, POU5F1) detected post-CM-AI processing (qRT-PCR; Supplementary Table ). Data are mean ± s.d.

    Article Snippet: Atrial TTN GFP cardiomyocytes were differentiated, laser-purified, and cryopreserved at the University of Michigan and then shipped overnight to Johns Hopkins University.

    Techniques: Flow Cytometry, Purification, Staining, Expressing, Quantitative RT-PCR

    a Post-thaw viability was similar between two hiPSC lines tested (TTN-GFP hiPSC-CM = 74.3 ± 7.4; 19.9.11 hiPSC-CM = 61.7 ± 2.9%, n = 3 separate batches per group). b Time-lapse imaging was used to quantify hiPSC-CM 2D monolayer formation kinetics following thaw, data is mean ± standard deviation at each time point. c Phase contrast and GFP images for each cell line tested in panel b on day 3.5 post thaw. d , e Representative calcium transient recordings from each hiPSC line at baseline and with isoproterenol (ISO, 200 nM) treatment. f Each cell line hiPSC-CMs responded to ISO with increased beat rate (TTN-GFP hiPSC-CM baseline = 68.9 ± 8.1; +ISO = 93.3 ± 10.3 bpm, n = 6) (19.9.11 hiPSC-CM baseline = 100.3 ± 15.6; +ISO = 130.0 ± 20.6bpm, n = 6). Paired t -test, *** P = 0.0001. g Each cell line hiPSC-CMs responded to 200 nM ISO with increased calcium wave propagation velocity (TTN-GFP hiPSC-CM baseline = 33.7 ± 5.9; +ISO = 46.9 ± 4.6 cm/s, n = 6) (19.9.11 hiPSC-CM baseline = 30.1 ± 3.4; +ISO = 37.2 ± 6.3 cm/s, n = 6). Paired t -test, *** P = 0.0003; ** P = 0.04.

    Journal: Communications Biology

    Article Title: AI-guided laser purification of human iPSC-derived cardiomyocytes for next-generation cardiac cell manufacturing

    doi: 10.1038/s42003-025-08162-0

    Figure Lengend Snippet: a Post-thaw viability was similar between two hiPSC lines tested (TTN-GFP hiPSC-CM = 74.3 ± 7.4; 19.9.11 hiPSC-CM = 61.7 ± 2.9%, n = 3 separate batches per group). b Time-lapse imaging was used to quantify hiPSC-CM 2D monolayer formation kinetics following thaw, data is mean ± standard deviation at each time point. c Phase contrast and GFP images for each cell line tested in panel b on day 3.5 post thaw. d , e Representative calcium transient recordings from each hiPSC line at baseline and with isoproterenol (ISO, 200 nM) treatment. f Each cell line hiPSC-CMs responded to ISO with increased beat rate (TTN-GFP hiPSC-CM baseline = 68.9 ± 8.1; +ISO = 93.3 ± 10.3 bpm, n = 6) (19.9.11 hiPSC-CM baseline = 100.3 ± 15.6; +ISO = 130.0 ± 20.6bpm, n = 6). Paired t -test, *** P = 0.0001. g Each cell line hiPSC-CMs responded to 200 nM ISO with increased calcium wave propagation velocity (TTN-GFP hiPSC-CM baseline = 33.7 ± 5.9; +ISO = 46.9 ± 4.6 cm/s, n = 6) (19.9.11 hiPSC-CM baseline = 30.1 ± 3.4; +ISO = 37.2 ± 6.3 cm/s, n = 6). Paired t -test, *** P = 0.0003; ** P = 0.04.

    Article Snippet: Atrial TTN GFP cardiomyocytes were differentiated, laser-purified, and cryopreserved at the University of Michigan and then shipped overnight to Johns Hopkins University.

    Techniques: Imaging, Standard Deviation

    a Cryopreserved TTN-GFP atrial hiPSC-CMs phase contrast and GFP images, 20×. b Zoomed image of sarcomere structures in hiPSC-CMs. c Representative time-space plots indicate functional monolayer electrophysiological activations across the width of each well of the 96-well plate (9 mm diameter). Rolipram increased hiPSC-CM monolayer beat rate. d Representative calcium transient traces indicating the effect of rolipram to increase calcium transient amplitude. e Rolipram increased 2D monolayer beat rate (VEH = 80.0 ± 11.8; 1.0 µM Rolipram = 113.3 ± 33.0; 10.0 µM Rolipram = 129.2 ± 9.4 bpm, n = 8 per group). One way ANOVA, multiple comparisons, * P = 0.01; *** P = 0.0004. f Rolipram increased calcium transient amplitude (VEH = 0.53 ± 0.17; 1.0 µM Rolipram = 0.72 ± 0.40; 10.0 µM Rolipram=1.22 ± 0.50 ∆F/F 0 , n = 8 per group). One way ANOVA, multiple comparisons, ** P = 0.004. g Rolipram increased calcium impulse conduction velocity (VEH = 23.5 ± 4.1; 1.0 µM Rolipram = 30.3 ± 17.6; 10.0 µM Rolipram = 47.9 ± 20.4 cm/s, n = 8 per group). One way ANOVA, Brown-Forsythe and Welch tests, multiple comparisons, * P = 0.02.

    Journal: Communications Biology

    Article Title: AI-guided laser purification of human iPSC-derived cardiomyocytes for next-generation cardiac cell manufacturing

    doi: 10.1038/s42003-025-08162-0

    Figure Lengend Snippet: a Cryopreserved TTN-GFP atrial hiPSC-CMs phase contrast and GFP images, 20×. b Zoomed image of sarcomere structures in hiPSC-CMs. c Representative time-space plots indicate functional monolayer electrophysiological activations across the width of each well of the 96-well plate (9 mm diameter). Rolipram increased hiPSC-CM monolayer beat rate. d Representative calcium transient traces indicating the effect of rolipram to increase calcium transient amplitude. e Rolipram increased 2D monolayer beat rate (VEH = 80.0 ± 11.8; 1.0 µM Rolipram = 113.3 ± 33.0; 10.0 µM Rolipram = 129.2 ± 9.4 bpm, n = 8 per group). One way ANOVA, multiple comparisons, * P = 0.01; *** P = 0.0004. f Rolipram increased calcium transient amplitude (VEH = 0.53 ± 0.17; 1.0 µM Rolipram = 0.72 ± 0.40; 10.0 µM Rolipram=1.22 ± 0.50 ∆F/F 0 , n = 8 per group). One way ANOVA, multiple comparisons, ** P = 0.004. g Rolipram increased calcium impulse conduction velocity (VEH = 23.5 ± 4.1; 1.0 µM Rolipram = 30.3 ± 17.6; 10.0 µM Rolipram = 47.9 ± 20.4 cm/s, n = 8 per group). One way ANOVA, Brown-Forsythe and Welch tests, multiple comparisons, * P = 0.02.

    Article Snippet: Atrial TTN GFP cardiomyocytes were differentiated, laser-purified, and cryopreserved at the University of Michigan and then shipped overnight to Johns Hopkins University.

    Techniques: Functional Assay